Thursday, December 29, 2011

Avastin disappoints against ovarian cancer (AP)

Avastin, the blockbuster drug that just lost approval for treating breast cancer, now looks disappointing against ovarian cancer, too. Two studies found it did not improve survival for most of these patients and kept their disease from worsening for only a few months, with more side effects.

The Genentech drug won approval in Europe last week for advanced ovarian cancer. But its maker has no immediate plans to seek the same approval in the United States. After talking with the Food and Drug Administration, "we do not believe the data will support approval" although no final decision has been made, said Charlotte Arnold, a spokeswoman for Genentech, part of the Swiss company Roche.

Results of the studies are in Thursday's New England Journal of Medicine.

In November, the FDA revoked Avastin's approval for breast cancer because it did not meaningfully extend life and can have serious side effects. Without approval, doctors can prescribe the drug but insurers may not pay. Treatment with it can cost $100,000 a year.

Avastin can still be sold for some colon, lung, kidney and brain cancers. The new research was aimed at adding ovarian cancer to the list.

One study, led by Dr. Robert Burger of Fox Chase Cancer Center in Philadelphia, involved nearly 1,900 women with advanced ovarian cancer given one of three treatment combinations. The time until the disease got worse was a median of 10 months in those given just chemotherapy; adding Avastin improved that by just one to four months for the other two groups.

Survival was similar among the groups, and side effects were higher among those on Avastin ? mostly high blood pressure but also some stomach and gut problems that needed treatment.

In the other study, led by researchers from England, more than 1,500 ovarian cancer patients were given chemo with or without Avastin. The drug kept cancer at bay just one to two months longer than chemo alone did, with more cases of high blood pressure. There was a trend toward improved survival for those on Avastin, but the difference was too small to say the drug was responsible.

Genentech helped pay for the studies and some of the researchers consult for the company.

Dr. Gary Lyman, a Duke University researcher who was on the FDA advisory panel that recommended revoking Avastin's approval for breast cancer, wrote in an email that he agreed with the company's decision not to seek approval for ovarian cancer.

"The situation is very similar" to the results in breast cancer, and approval is unlikely unless a biological marker or test can show which patients might benefit, he wrote.

About 220,000 new cases of ovarian cancer are diagnosed each year around the world, and it causes 140,000 deaths. In the United States, the National Cancer Institute estimates 22,000 new cases and 15,000 deaths each year.

___

Online:

Studies: http://www.nejm.org

___

Marilynn Marchione can be followed at http://twitter.com/MMarchioneAP

Source: http://us.rd.yahoo.com/dailynews/rss/diseases/*http%3A//news.yahoo.com/s/ap/20111228/ap_on_he_me/us_med_avastin_ovarian_cancer

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Wednesday, December 28, 2011

Crazy ?Spam? Email About Print Cancellation *Is* Actually From The New York Times

Screen Shot 2011-12-28 at 11.24.33 AMIf you're a New York Times subscriber -- or even if you're not -- you may have received that following email this morning, implying that you have cancelled your subscription. Many many people did, it's all over the tweets.? Even though the email was sent from an address that had sent out legitimate emails in the past, "email.newyorktimes.com," it wasn't actually from the New York Times, as some of their more tech hipster reporters and their official Twitter account confirmed, "If you received an email today about canceling your NYT subscription, ignore it. It's not from us.?

Source: http://feedproxy.google.com/~r/Techcrunch/~3/vfOCgeNWV9Q/

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Rapper Nelly Being Sued By American Express For $20,000

Rapper Nelly Being Sued By American Express For $20,000

Rapper Nelly is facing legal woes after failing to pay a large credit card bill. American Express claim the rapper hasn’t pay a bill of [...]

Rapper Nelly Being Sued By American Express For $20,000 Stupid Celebrities Gossip Stupid Celebrities Gossip News

Source: http://stupidcelebrities.net/2011/12/26/rapper-nelly-being-sued-by-american-express-for-20000/

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Tuesday, December 27, 2011

Women Beat Men to Jobs as Japans Mancession Spurs Deflation

December 27, 2011, 4:41 AM EST

By Aki Ito and Toru Fujioka

Dec. 27 (Bloomberg) -- Three times a week, Seiya Ogawa bikes to an unemployment center in Kadoma, home to Panasonic Corp., looking for work to help pay for his son?s final year at college.

?At this point, I?m willing to take any job,? said the 49-year-old, who assembled electronic circuit boards in what was once a bustling manufacturing suburb of Osaka, Japan?s third- largest city. This month, it?s officially one year since he first signed on at the center, and ?it?s like my humanity?s been stripped from me,? he said.

Ogawa and his son rely on the incomes of his wife and daughter, a social role reversal that is spreading in Japan as factories and building companies fire workers and services that hire mostly women add employees. The new jobs pay lower average wages, making it harder for Prime Minister Yoshihiko Noda to spur consumer spending and pull the world?s third-largest economy out of a decade of deflation. The increasing burden as breadwinners also gives women less incentive to marry and have children early in a country that already has the fastest-aging population in the developed world.

?With Japanese companies increasingly moving abroad and a shrinking population making growth in construction work unlikely, these sectors just can?t absorb male workers the way they used to,? said Toshihiro Nagahama, chief economist at Dai-Ichi Life Research Institute in Tokyo. ?Nominal wages are falling and falling as a result. This mancession is far from over.?

National Pride

Japan?s economy is shifting from monozukuri, or making things -- which the nation prides itself on -- to services, especially those catering to the 29 million seniors over age 64. Manufacturing and building industries, where seven out of 10 staff are male, will lose 4 million positions this decade, according to Tokyo-based Works Institute, funded by employment- services provider Recruit Co. Health care, 74 percent female, added people at the fastest pace across all industries in the past three years, growing 16 percent, Labor Ministry data show.

The shift is accelerating, thanks to a near record-high currency that?s wiping out profits at exporters including Panasonic and Sony Corp., giving the government no time to ease the transition. Panasonic forecast its biggest annual loss in a decade this fiscal year, while Sony estimated it will lose 90 billion yen ($1.2 billion).

Panasonic and Sony shares have slumped 45 percent and 53 percent this year, helping pull the benchmark Topix index 20 percent lower. At the same time, Message Co., the nation?s second-biggest operator of nursing homes by number of rooms, has risen 1.6 percent, and Nichii Gakkan Co., operator of the largest number of homes, is up 25 percent.

?Future of Japan?

Services such as nursing and health care are ?the future of Japan,? said Curtis Freeze, founder of Honolulu-based Prospect Asset Management Inc., who is considering adding Message to the $300 million that Prospect manages because its employment policies may reduce staff-turnover costs. Manufacturers ?are in the middle of restructuring, and they?re going to struggle. It?s the smaller services companies that will do most of the hiring.?

Health care, with 19 percent of working women, isn?t the only field to add jobs in the past three years: Education -- another profession where women outnumber men -- as well as research, restaurants and real estate also have grown, even as Japan lost a net 12.1 million positions.

Forty-two percent of people employed in 2010 were women, the highest share since the Labor Ministry made comparable data available in 1973, when the figure was 38.5 percent.

?Really Tough?

?It?s really tough right now,? said Reiko Sato, 31, at the government employment office near her home in Tokyo. ?It?s the end of the year, so there are lots of short-term positions at department stores or restaurants that everyone?s competing to get. It?s easier for the girls, because that?s who the stores want. I just feel bad for the men who have to come here. They probably won?t have something in time for the New Year.?

Manufacturing, where men outnumber women by more than 2-to- 1, is still Japan?s largest employer, accounting for about 16 percent of its 62.5 million workers. In construction, the ratio of men to women is 6-to-1. Since October 2008, the former shrank payrolls by 9 percent and the latter by 11 percent. Meanwhile, the health-care workforce will grow 32 percent from 2010 to 2020, according to Works Institute.

Pay Gap

As a result, one of the developed world?s biggest gender- pay gaps -- second only to South Korea and roughly double the average in the Organization for Economic Cooperation and Development -- is narrowing. Women between 30 and 34 earned an average 2.99 million yen last year, 69 percent of the 4.32 million yen for men, according to National Tax Agency data. That?s up from 55 percent in 1978.

The increase may help shift consumer spending toward services women prefer, such as traveling and dining out, and away from durable goods including cars and electronics, said Kyohei Morita, chief Japan economist at Barclays Capital in Tokyo. HIS Co., Japan?s largest listed travel agency, has risen 4.3 percent this year, to 2,141 yen.

?It?s because I work that I can go on these trips and buy my favorite makeup,? said Ayumi Ohtaki, a 27-year-old call- center operator in Tokyo who earns 240,000 yen a month. While she?s in no hurry to marry, she said she would want to keep her job after her wedding to ensure she could continue to buy the things she wants.

?If the money?s just from my husband, I wouldn?t be able to do anything fun,? she said.

Birth Rate

With women like Ohtaki marrying later and delaying starting a family, and more men struggling to find work, Japan?s falling birth rate is likely to get worse, said Mary Brinton, a sociology professor at Harvard University in Cambridge, Massachusetts, who studied the lives of young Japanese men shut out of well-paid, full-time work in the 1990s.

The number of babies born in 2010 was 1.07 million, down from 1.19 million in 2000, according to the Health, Labor and Welfare Ministry.

?This so-called mancession is going to cause continuing problems for the marriage rate and birth rate,? she said. ?Many young Japanese men say they want to have a stable job before they consider marrying.?

Even so, the shift toward more female employees isn?t likely to boost overall consumer spending because the factory jobs being lost paid more than the newly created service positions. Social services and nursing paid an average 229,732 yen a month last year, 63 percent of the 362,340 yen for factory workers and 62 percent of the 373,288 yen earned in construction, according to the labor ministry.

?The reality is that women get paid less,? Morita said.

Global Trend

The trend of women replacing men in Japan?s workforce mirrors a similar shift in other developed nations as companies cut back payrolls. Last year, the average male unemployment rate among the OECD countries was 8.5 percent, compared with 8.1 percent for women, according to the organization?s website. In 2000, the situation was reversed, with 5.8 percent of men jobless and 6.8 percent of female workers.

Japan?s unemployment rate in 2010 was 5.4 percent for men and 4.6 percent for women, a record gap. Joblessness may rise to 7.1 percent for men and 5.9 percent for women by 2020, Works Institute estimates.

That?s a bleak outlook for Ogawa, who lives alongside Kadoma?s rusting, shuttered factories, which once drew laborers from across Japan as they boomed with the Panasonic headquarters they surround. He says the stagnation has changed the attitude of young people in their 20s like his son and daughter, who hoard the money they earn rather than spending it.

?It?s hard to tell them to aim high when I?m struggling to find a job,? Ogawa said. ?I don?t dare talk about my good times when I was their age; they just wouldn?t understand.?

--With assistance from Kanoko Matsuyama and Eleanor Warnock in Tokyo. Editor: Adam Majendie, Melinda Grenier.

To contact the reporters on this story: Aki Ito in Tokyo at aito16@bloomberg.net; Toru Fujioka in Tokyo at tfujioka1@bloomberg.net

To contact the editor responsible for this story: Paul Panckhurst at ppanckhurst@bloomberg.net

Source: http://c.moreover.com/click/here.pl?r5665728805

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Obama rakes in campaign cash (Daily Caller)

The re-election campaign of President Obama and the Democratic National Committee are on track to net $60 million for the fourth quarter of the year, Reuters reports.

Obama had already raised roughly $155 million through September in an effort to raise more than $750 million for next November?s election.

?Enthusiasm for the White House?s policies has been steadily increasing and it will keep increasing,? major Democratic fundraiser Steven Cohen told the news service.

According to Cohen, the GOP?s bungled handling of the payroll tax fight is inspiring contributors to give more to Obama?s re-election campaign.

?Among the people who I have talked to, they are seeing a real demonstration of the president?s commitment to stand his ground,? he said.

The campaign had hoped to bring in $55 million last quarter. Instead they raised $70 million, even though last summer?s debt ceiling fight had forced President Obama to stay in Washington and cancel fundraisers in other parts of the country.

The 2012 election is already on its way to becoming the most expensive in history, with Obama expected to raise more than the record $750 million he had in the bank in 2008. Former Massachusetts Gov. Mitt Romney, among the front-runners for the GOP nomination, is expected to raise at least $20 million this quarter.

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Maher reaction to Broncos' loss: 'Jesus just f--ked #TimTebow bad!'

Source: http://us.rd.yahoo.com/dailynews/rss/democrats/*http%3A//news.yahoo.com/s/dailycaller/20111225/pl_dailycaller/obamarakesincampaigncash

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Thursday, December 22, 2011

Kim Jong Il body displayed behind glass, flowers

ALTERNATE CROP OF TOK912 OF DEC. 20, 2011 - In this image made from KRT television, the body of North Korean leader Kim Jong Il is laid in a memorial palace in Pyongyang, North Korea, Tuesday, Dec. 20, 2011. (AP Photo/KRT) TV OUT NORTH KOREA OUT

ALTERNATE CROP OF TOK912 OF DEC. 20, 2011 - In this image made from KRT television, the body of North Korean leader Kim Jong Il is laid in a memorial palace in Pyongyang, North Korea, Tuesday, Dec. 20, 2011. (AP Photo/KRT) TV OUT NORTH KOREA OUT

In this image made from KRT television, Kim Jong Un, center, North Korean leader Kim Jong Il's youngest known son and successor, visits the body of senior Kim with top military and Workers' Party officials in a memorial palace in Pyongyang, North Korea, Tuesday, Dec. 20, 2011. (AP Photo/KRT) TV OUT NORTH KOREA OUT

In this image made from KRT television, the body of North Korean leader Kim Jong Il is laid in a memorial palace in Pyongyang, North Korea, Tuesday, Dec. 20, 2011. (AP Photo/KRT) TV OUT NORTH KOREA OUT

People watch a TV screen showing the body of North Korean leader Kim Jong Il at Seoul Railway Station in Seoul, South Korea, Tuesday, Dec. 20, 2011. North Korean state television announced Monday that North Korean leader Kim Jong Il died on Saturday. The letters on the screen read" Korean Central TV opens Kim Jong-Il's body". AP Photo/Ahn Young-joon)

Condolence wreaths offered by mourners are on display in front of a picture of late North Korean leader Kim Jong Il at the North Korean custom office in Dandong, China, Tuesday, Dec. 20, 2011. North Korea's leader Kim Jong Il died Saturday of a massive heart attack brought about by overwork and stress, according to the North's media. (AP Photo/Andy Wong)

(AP) ? North Korea displayed the body of ruler Kim Jong Il in a glass coffin surrounded by red flowers Tuesday, and his young heir was one of the first to pay respects ? a strong indication that a smooth leadership transition was under way.

As the country mourned for a second day with high-level visits to Kim's body at a memorial palace and public gatherings of weeping citizens, state media fed a budding personality cult around his youngest known son and anointed heir, Kim Jong Un, hailing him as a "lighthouse of hope."

Kim's body was wrapped in red cloth and surrounded by blossoms of his namesake flowers, red "kimjongilia." As solemn music played, Kim Jong Un ? believed to be in his late 20s ? entered the hall to view his father's bier, surrounded by military honor guards. He observed a moment of solemn silence, then circled the bier, followed by other officials.

Outside one of the capital's main performance centers, mourners carried wreaths and flowers toward a portrait of Kim Jong Il. Groups were allowed to grieve in front of the portrait for a few minutes at a time.

"We will change today's sorrow into strength and courage and work harder for a powerful and prosperous nation, as our general wanted, under the leadership of the new General Kim Jong Un," U Son Hui, a Pyongyang resident, told The Associated Press.

The announcement Monday of Kim's death over the weekend raised acute concerns in the region over the possibility of a power struggle between the untested son and rivals, in a country pursuing nuclear weapons and known for its unpredictability and secrecy.

But there have been no signs of unrest or discord in Pyongyang's somber streets.

With the country in an 11-day period of official mourning, flags were flown at half-staff at all military units, factories, businesses, farms and public buildings. The streets of Pyongyang were quiet, but throngs of people gathered at landmarks honoring Kim.

Kim's bier was decorated by a wreath from Kim Jong Un along with various medals and orders. The body was laid out in the Kumsusan Memorial Palace, a mausoleum where the embalmed body of Kim's father ? national founder Kim Il Sung ? has been on display in a glass sarcophagus since his death in 1994.

Kim Jong Il died of a massive heart attack on Saturday caused by overwork and stress, according to the North's media. He was 69 ? though some experts question the official accounts of his birth date and location.

The state funeral for Kim is set for Dec. 28 in Pyongyang, to be followed by a national memorial service the next day, according to the North's state media. North Korean officials say they will not invite foreign delegations and will allow no entertainment during the mourning period.

Since Kim's death the media have stepped up their lavish praise of the son, indicating an effort to strengthen a cult of personality around him similar to that of his father and ? much more strongly ? of Kim Il Sung.

The Korean Central News Agency on Tuesday described Kim Jong Un as "a great person born of heaven," a propaganda term previously used only for his father and grandfather. The Rodong Sinmun, the newspaper of the ruling Workers' Party, added in an editorial that Kim Jong Un is "the spiritual pillar and the lighthouse of hope" for the military and the people.

It described the twenty-something Kim as "born of Mount Paektu," one of Korea's most cherished sites and Kim Jong Il's official birthplace. On Monday, the North said in a dispatch that the people and the military "have pledged to uphold the leadership of comrade Kim Jong Un" and called him a "great successor" of the country's revolutionary philosophy of juche, or self reliance.

Young Koreans, the North reported, "are burning with the faith and will to remain loyal to Kim Jong Un."

But concerns remain over whether the transition will be a smooth one.

South Korea put its military on high alert, and experts warned that the next few days could be a crucial turning point for the North, which though impoverished by economic mismanagement and repeated famine, has a relatively well-supported, 1.2 million-strong armed forces.

South Korea offered condolences to the North Korean people, but the government said no official delegation will be traveling from Seoul to Pyongyang to pay their respects.

Kim's death could set back efforts by the United States and others to get Pyongyang to abandon its nuclear weapons ambitions. Concerns are also high that Kim Jong Un ? being young and largely untested ? may feel he needs to prove himself by precipitating a crisis or displaying his swagger on the international stage.

Kim Jong Il was in power for 17 years after the death of his father, and was groomed for power years before that. Kim Jong Un only emerged as the likely heir over the past year.

North Korea conducted at least one short-range missile test Monday, South Korean officials said. But they saw it as a routine drill.

"The sudden death of Kim Jong Il has plunged the isolated state of North Korea into a period of major uncertainty. There are real concerns that heir-apparent Kim Jong Un has not had sufficient time to form the necessary alliances in the country to consolidate his future as leader of the country," said Sarah McDowall, a senior analyst with U.S.-based consultants IHS.

Some analysts, however, said Kim's death was unlikely to plunge the country into chaos because it already was preparing for a transition. Kim Jong Il indicated a year ago that Kim Jong Un would be his successor, putting him in high-ranking posts.

___

Reported from Pyongyang by Associated Press Television News senior video journalist Rafael Wober. AP writers Jean H. Lee, Foster Klug, Hyung-jin Kim, Sam Kim and Eric Talmadge contributed to this story.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2011-12-20-AS-Kim-Jong-Il/id-54b02d53a52b4dd2aa88fdbaeb8681f0

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Monday, December 19, 2011

Android 4.0.2 update now rolling out to GSM Galaxy Nexus

Android Central

The GSM (international) version of the Samsung Galaxy Nexus has just received its update to Android 4.0.2, hot on the heels of the Verizon version, which got the update on its launch day. Several GSM Nexus owners are now reporting that they've received the new version of Android, which carries the build number ICL53F.

The update weighs just 8.7MB, and according to the update message contains "important bug fixes", most likely the same fixes detailed in Verizon's latest update statement (excluding the LTE-specific stuff, of course).

To see if your phone is ready to receive the update, head to Settings > About phone > System updates. If it's still telling you you're already up-to-date, you may have to wait a few days before it's your turn to be updated. Don't want to wait? If you're comfortable with unlocking bootloaders and fiddling around with command-line stuff, once the files URL is located you'll be able to download them from Google and use Jerry's clever manual update method.

Now we get ready for Android 4.0.3.  Isn't having a Nexus phone grand?



Source: http://feedproxy.google.com/~r/androidcentral/~3/NtvaItI6PUE/story01.htm

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