'Drake went through everything as far as being a new artist and on the same label,' Twist says of his Young Money comrade. By Rob Markman
Lil Twist Photo: MTV News
Celebrity Favorites: Lil Twist Putting out a debut album has to be stressful, especially when faced with continual delays, but lucky for Lil Twist he has had the right people in his corner.
"I talked to my mom mostly, and then Wayne," Twist told Mixtape Daily about who he sought advice from each time his Don't Get It Twisted album got pushed back. "Wayne and [Young Money president] Mack [Maine] are like my brothers, and Drake also. Drake is always a good person to give advice."
Twisted was originally slated for a 2011 release and has already produced a number of notable singles, including "Love Affair" with Lil Wayne and "Turnt Up" with Busta Rhymes. Now, the LP has a March 20 release date, which, to Twist, appears to be rock solid. 2 Chainz and Twist's buddy Justin Bieber are also expected to appear. "We're getting ready to drop that record 'Wherever You Are.' Y'all will have that real soon," Twist told MTV News of the high-powered collaboration. "It's a fun record. Justin killed it. He's, like, rap-singing on it; another different sound for Justin."
Don't Get It Twisted has been complete for some time, but Twist simply had to wait things out.
"Drake went through everything as far as being a new artist and on the same label, seeing how everything went down," he said of his Young money labelmate. "So he was just letting me know what was going to go down, how I need to go about it and just how to overcome the stress that I was feeling coming out with this album."
Are you ready for Lil Twist's Don't Get It Twisted? Tell us in the comments!
Unexpected discovery opens up new opportunities for targeting cancerPublic release date: 10-Jan-2012 [ | E-mail | Share ]
Contact: John Schwabe js336@le.ac.uk 44-116-229-7038 University of Leicester
University of Leicester scientists announce a major advance in understanding the regulation of an important cancer target in Nature paper
Scientists at the University of Leicester have opened up a whole new approach to the therapeutic intervention for a family of anti-cancer drug targets, thanks to a completely new and unexpected finding.
Professor Schwabe and his colleagues, Drs Watson, Fairall and Santos, have published their research this week in leading science magazine Nature detailing a new understanding of how transcriptional repression complexes work. Their work, which is based around determining atomic resolution structures of medically important bio-molecular complexes, has been ongoing for six years, and is currently funded through a 1.4 million grant from The Wellcome Trust.
Transcriptional regulatory complexes play an important role in the regulation of development, differentiation, cancer and homeostasis. Transcription is the process of creating a complementary RNA copy of a sequence of DNA and is the first step in the process of gene expression.
Professor John Schwabe, of the University of Leicester's Department of Biochemistry, said: "We have discovered a completely new and unexpected link between inositol phosphate signalling (in this case IP4) and the regulation of histone deacetylase enzymes and hence transcriptional repression or gene silencing.
"In simple terms, we have shown that IP4 acts as a natural signalling molecule to regulate histone deacetylase enzymes which play a key role in regulating gene expression. Apart from the considerable intellectual importance of understanding how transcription is regulated, repression complexes are important therapeutic targets for a number of cancers including several types of leukaemia.
"Our research identifies several new means to potentially target histone deacetylase enzymes therapeutically: either by using drugs to prevent IP4 binding to the enzyme or by interfering with the pathway through which the body makes IP4. Thus this work opens up a whole new area of research with potential for new drugs and a new approach to targeting histone deacetylase enzymes."
Professor Schwabe said that this research is not only an exciting breakthrough in the field, but is also a technological feat relying on both the excellent research facilities in Leicester and the microfocus X-ray source at the Diamond Light Source in Oxfordshire.
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Note to newsdesk: For more information, please contact Professor Schwabe on : +44(0)116 229 7038; email js336@le.ac.uk
The Wellcome Trust is a global charitable foundation dedicated to achieving extraordinary improvements in human and animal health. It supports the brightest minds in biomedical research and the medical humanities. The Trust's breadth of support includes public engagement, education and the application of research to improve health. It is independent of both political and commercial interests.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Unexpected discovery opens up new opportunities for targeting cancerPublic release date: 10-Jan-2012 [ | E-mail | Share ]
Contact: John Schwabe js336@le.ac.uk 44-116-229-7038 University of Leicester
University of Leicester scientists announce a major advance in understanding the regulation of an important cancer target in Nature paper
Scientists at the University of Leicester have opened up a whole new approach to the therapeutic intervention for a family of anti-cancer drug targets, thanks to a completely new and unexpected finding.
Professor Schwabe and his colleagues, Drs Watson, Fairall and Santos, have published their research this week in leading science magazine Nature detailing a new understanding of how transcriptional repression complexes work. Their work, which is based around determining atomic resolution structures of medically important bio-molecular complexes, has been ongoing for six years, and is currently funded through a 1.4 million grant from The Wellcome Trust.
Transcriptional regulatory complexes play an important role in the regulation of development, differentiation, cancer and homeostasis. Transcription is the process of creating a complementary RNA copy of a sequence of DNA and is the first step in the process of gene expression.
Professor John Schwabe, of the University of Leicester's Department of Biochemistry, said: "We have discovered a completely new and unexpected link between inositol phosphate signalling (in this case IP4) and the regulation of histone deacetylase enzymes and hence transcriptional repression or gene silencing.
"In simple terms, we have shown that IP4 acts as a natural signalling molecule to regulate histone deacetylase enzymes which play a key role in regulating gene expression. Apart from the considerable intellectual importance of understanding how transcription is regulated, repression complexes are important therapeutic targets for a number of cancers including several types of leukaemia.
"Our research identifies several new means to potentially target histone deacetylase enzymes therapeutically: either by using drugs to prevent IP4 binding to the enzyme or by interfering with the pathway through which the body makes IP4. Thus this work opens up a whole new area of research with potential for new drugs and a new approach to targeting histone deacetylase enzymes."
Professor Schwabe said that this research is not only an exciting breakthrough in the field, but is also a technological feat relying on both the excellent research facilities in Leicester and the microfocus X-ray source at the Diamond Light Source in Oxfordshire.
###
Note to newsdesk: For more information, please contact Professor Schwabe on : +44(0)116 229 7038; email js336@le.ac.uk
The Wellcome Trust is a global charitable foundation dedicated to achieving extraordinary improvements in human and animal health. It supports the brightest minds in biomedical research and the medical humanities. The Trust's breadth of support includes public engagement, education and the application of research to improve health. It is independent of both political and commercial interests.
[ | E-mail | Share ]
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Those who know Rick Santorum, the former Pennsylvania senator and now high-flying presidential candidate, know that he is a professional wrestling fanatic. Chris Jericho, CM Punk, Daniel Bryan ? those guys are heroes of his.
On Saturday night in Manchester, N.H., Santorum found himself at the center of the ring in the biggest battle royale of his political career. The pesky Pennsylvanian, known as a brawling, no-holds-barred lawmaker before being tossed off the solon circuit in 2006, had to prove that he could go toe-to-toe with local favorite Mitt Romney, whose ?Massachusetts Mauler? nickname is something of an ironic misnomer for most fight fans.
Also bouncing about Saturday night?s elimination chamber were Rick ?The Bunkhouse Baron? Perry, desperately trying to keep from being tossed over the top rope; Newt ?The Georgia Grinch? Gingrich, an old pro and former fan favorite whose white hat has gotten a big begrimed lately; Ron ?Dr No? Paul, a wily veteran venerable enough to have tangled with Gorgeous George; and Jon ?The Ghost? Huntsman, a little-known newcomer who could be retiring from the ring after this weekend?s back-to-back Survivor Island episodes from New Hampshire.
Not unlike a wrestling smackdown, the Saturday night debate got off to a raucous start, with Santorum stalking Romney, Paul chasing Santorum and Paul calling Gingrich ?a chicken hawk.? The debate settled down after awhile, and by the end the referee?s job was fairly easy.
WINNERS
MITT ROMNEY: Think of the former Massachusetts governor standing at the center of the ring stiff-arming his opponents while looking over their heads toward President Obama and the general election. He was rattled at times tonight, particularly in a extended exchange with moderator George Stephanopolous over contraception and the right to privacy, but for the most part neither moderators nor his opponents on stage were able to shake his he-could-be-president bearing.
JON HUNTSMAN: The former Utah governor won?t be getting anybody?s nomination this year; in fact, this weekend?s back-to-back debates may mean goodbye for the former Utah governor; he may not make it to South Carolina. Could it be that he?s running for the 2016 nomination of a more moderate Republican Party? Whatever happens this year, his sensible and balanced answers suggest that he won?t fade into political oblivion.
RON PAUL: The libertarian Texas congressman won?t be getting the nomination either ? the Republican nomination, at least ? but in his cranky old uncle?s voice, he was successful yet again at forcing his opponents on stage and his fellow Republicans in general to face unpleasant truths about the costs of war, problems of racism and other issues they might prefer to avoid. (And he didn?t rule out a third-party run.)
LOSERS
RICK SANTORUM: In order to establish himself as a legitimate front-runner, Santorum needed to knock Romney off his game. He didn?t. Although he came across, as usual, as knowledgeable and experienced, he also came across, as usual, as churlish and unpleasant ? in other words, un-presidential.
NEWT GINGRICH: The former House speaker and recent ?flavor of the month? did fine but did nothing to shake the impression that the nomination remains Romney?s to lose.
RICK PERRY: For long periods, it seemed that the Texas governor had decamped to the concession stand. On the few occasions that he did get in on the conversation, his remarks ? about Obama?s war on religion, about sending troops back into Iraq ? sounded not bold and memorable, as he surely intended, but merely intemperate.
LINES YOU MIGHT REMEMBER THE NEXT MORNING
?When I was drafted, I was married and had two kids, and I went.? (Paul in a contretemps with Gingrich over whether he dodged the draft during the Vietnam War)
?I would send troops back into Eye-Raq.? (Perry)
?Contraception? It?s working just fine.? (Romney)
?I?m glad we?re off the contraception discussion.? (Huntsman, noting that he?s the father of seven children)
?There are no classes in America.? (Santorum)
?He doesn?t understand the situation.? (Hunstman, delivered in Mandarin Chinese)
Abu Dhabi, 7th Jan. 2012 (WAM) ? The UAE tolerant inter-faith policy adopted by the UAE under the wise leadership of President His Highness Sheikh Khalifa bin Zayed Al Nahyan has drawn praise from the Coptic Orthodox Church of Egypt at a Christmas mass here last night.
In the name of Pope Shenouda III of Alexandria and Patriarch of Saint Mark, Ishaq Al Anba Bishoy, Pastor of Al Anba Antonio Orthodox Coptic Cathedral Church in Abu Dhabi, paid gratitude in a Christmas mass sermon last night to Sheikh Khalifa, Vice President and Prime Minister of the UAE and Ruler of Dubai His Highness Sheikh Mohammed bin Rashid Al Maktoum, Their Highnesses Rulers of Emirates, His Highness General Sheikh Mohammed bin Zayed Al Nahyan, Crown Prince of Abu Dhabi and Deputy Supreme Commander of the UAE Armed Forces, government and people of the UAE, for the support and assistance awarded to Christians to perform their religious activities with full freedom and safety.
He painted Sheikh Khalifa?s tolerant policy as a ? message of love and peace to to all countries of the world which renders the spirit of brotherhood and love that should prevail among followers of divine religions, particularly on our dear Arab land, birthplace of religions and cradle of civilisations and cultures.
Both Muslims and Christians lit candles at the Cathedral and prayed to The Almighty for peace and harmony on the Arab World and beyond.
Ali Al Hashimi, Religious and Judicial Adviser at the Ministry of Presidential Affairs, who attended the mass along with other officials, stressed the importance of maintaining common factors and noble values bringing both Muslims and Christians together.
?Christ?s Birthday is a revered occasion to Muslims,? he said, noting that the Holy Quran mentioned the miracle of His birth.
WASHINGTON: President Barack Obama rolled out a slimmed down defense strategy Thursday, pledging to maintain the United States position as the world?s dominant military power, remaining vigilant to ?threats? in the Middle East while signaling a shift away from large ground wars.
?Our military will be leaner but the world must know ? the United States is going to maintain our military superiority with armed forces that are agile, flexible and ready for the full range of contingencies and threats,? Obama told a news briefing at the Pentagon.
Emphasizing the American presence in the Asia-Pacific region, where there is growing U.S. rivalry with an increasingly assertive China, Obama cautioned the military would remain vigilant in the Middle East.
At a time of tight budgets at home Obama?s strategy is aimed at absorbing hundreds of billions of dollars in defense budget cuts, saying the U.S. will retain the best-equipped military in American history but with slimmed down forces.
In a rare appearance in the Pentagon press briefing room, the president announced that the military will be reshaped over time with an emphasis on countering terrorism, maintaining a nuclear deterrent, protecting the U.S. homeland and ?deterring and defeating aggression by any potential adversary.?
Obama announced no new capabilities or defense initiatives. He described a U.S. force that will retain much of its recent focus, with the exception of fighting a large-scale, prolonged conflict like the newly ended Iraq mission or the continuing war in Afghanistan.
Saying the country was ?turning a page? on a decade of war, Obama hinted at a reduced U.S. military presence in Europe and says Asia will be a bigger priority. It also emphasized improving U.S. capabilities in the areas of cyber warfare and missile defense.
China is a particular worry because of its economic dynamism and rapid defense buildup. A more immediate concern is Iran, not only for its threats to disrupt the flow of international oil but also for its nuclear ambitions.
Defense Secretary Leon Panetta and several top military brass lined up on the stage behind him, underscoring Pentagon support for cuts that Panetta and others said they know will be criticized as too drastic.
Panetta said that smaller military budgets will mean some tradeoffs and that the U.S. will take on ?some level of additional but acceptable risk.? But Panetta said that at this point in history, in a changing world, the Pentagon would have been forced to make a strategy shift anyway. He says the money crisis merely forced the government?s hand.
In a preamble to the strategy, Obama wrote: ?As we end today?s wars and reshape our armed forces, we will ensure that our military is agile, flexible and ready for the full range of contingencies. The document is titled, ?Sustaining U.S. Global Leadership: Priorities for 21st Century Defense.?
Obama?s decision to announce the strategy himself underscores the political dimension of Washington?s debate over defense savings. The administration says smaller Pentagon budgets are a must but will not come at the cost of sapping the strength of a military in transition, even as it gets smaller.
In a presidential election year, the strategy gives Obama a rhetorical tool to defend his Pentagon budget-cutting choices. Republican contenders for the White House already have criticized Obama on a wide range of national security issues, including missile defense, Iran and planned reductions in ground forces.
Obama also wants the new strategy to represent a pivot point in his stewardship of defense policy, which has been burdened throughout his presidency by the wars he inherited and their drag on resources.
The new strategy moves the U.S. further from its longstanding goal of being able to successfully fight two major regional wars ? like the 1991 Gulf War to evict Iraqi forces from Kuwait or a prospective ground war in Korea ? at the same time.
The strategy document announced by Obama contained no specifics on the size of expected troop reductions; the Army and Marine Corps already are set to shrink beginning in 2015. The document said the Pentagon will have to find savings in pay and health care benefits for members of the military, but it offered no specifics.
It made clear that while some current missions of the military will be curtailed, none will be scrapped entirely.
?Wholesale divestment of the capability to conduct any mission would be unwise, based on historical and projected uses of U.S. military forces and our inability to predict the future,? the document said.
The massive $662 billion defense budget planned for next year is $27 billion less than Obama wanted and $43 billion less than Congress gave the Pentagon this year.
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Public release date: 10-Jan-2012
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